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Introduction |
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The ICCB-Longwood Investigator Initiated Screening Program assists academic researchers in carrying out
high-throughput screens of chemical libraries to identify new tools
for biological research. The ICCB-Longwood screening facility is built
around modular work stations, and assays are generally carried
out in 384-well plates. The ICCB-Longwood compound collection is continuously
growing, and over 125,000 compounds are currently available for
screening. The facility employs a staff-assisted screening model,
in which investigators using the facility are provided with access
to compound libraries and training in the use of some instruments,
such as liquid handling equipment,
plate readers, and screening microscopes. Staff members run all
complex automation for screens.
The ICCB-Longwood screening effort is expanded through close interactions
with two other Harvard Medical School-affiliated programs, the
National Screening Laboratory for the Regional Centers of Excellence in
Biodefense and Emerging Infectious Disease (NSRB)
and the Laboratory
for Drug Discovery (LDDN).
Together, these three screening efforts focus on broadly different
areas, but all share the goal of using small molecule screens to
analyze a variety of biological processes. Compound libraries and
other resources are shared among the three groups, with each providing
support in its particular area of expertise.
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